This textbook chapter (pp 65-92) presents results on enhancing robustness of quantum systems with uncertainties using the sampling-based learning control (SLC) method. In Sect. 4.2, the SLC method is applied to state control of superconducting qubits, robust control of photoassociation of O+H and synchronizing a laser with molecules for charge transfer. Robust control based on SLC and b-GRAPE is presented for generating quantum gates in Sect. 4.3 and SLC of open quantum systems is investigated in Sect. 4.4.